Babesiosis is a rare ailment that can occur in mild or severe forms. The mild form of babesiosis is asymptomatic and may resolve itself without any treatment. On the other hand, the severe form of babesiosis exhibits conspicuous symptoms such as fevers, chills, fatigue, and aches. The symptoms and pathogenesis of babesiosis closely resemble those of malaria infection. In addition, both parasites belong to the phylum Apicomplexa making it hard to distinguish between the two infections. The immune system plays a crucial role in controlling babesiosis thereby making immunocompromised individuals and the elderly highly predisposed to infections. It is also known that most symptoms experienced during the illness are consequences of the host immune response against the disease. Therefore, there is a need to establish efficient diagnostic tools to help in the distinction between babesiosis and malaria infections and ensure that patients get timely interventions to minimize the loss of lives from babesiosis.
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