Many signaling pathways include tiny, non-protein, water-soluble molecules or ions known as second messengers (Recce, 2005). Research has revealed that epinephrine is only one of many hormones and other signal molecules that trigger the formation ofÂ cyclic adenosine monophosphateÂ (cAMP), a cytosolic concentrated compound. The immediate effect of cAMP is usually the activation of a serine/threonine kinase caned protein,Â kinaseÂ A. Calcium is more widely used than cAMP as a second messenger in both in both G-protein and receptor tyrosine kinase pathways, because its concentration in the cytosol is normally much lower than the concentration outside the cell. In response to a signal relayed by a signal transduction pathway, the cytosolic calcium level may rise. Other second messengers, such asÂ inositol trisphosphateÂ (IP3) andÂ diacylglycerolÂ (DAG), are also involved in the process of calcium release. Because IP3 acts before calcium in these pathways, calcium may be considered aÂ third messenger. The termÂ second messengerÂ is given to all small, non-protein components of signal transduction pathways.
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