SNPs Structure and the Binding Ability of PTC
The TAS2R38 is responsible for the bitter taste experienced when one comes into contact with PTC.3Â An analysis of SNPâ€™s nucleotide helps reveal the receptor responsible for this observation. Studies have determined that the G protein-coupled receptor is the one responsible for the experience. In this regard, the PTC acts as the ligand.4Â Binding, in this case, results from a process known as molecular docking (see figure 1). Such a process (also known as binding) must occur at a given site. In this case, the receptor activation occurs on helices 6 and 7. It is believed that N103 residue is an active component of PTC binding. The shape and size of the binding cavity are defined by a number of factors. They include W99, M100, and S259. The binding process largely relies on receptor activation. M100, V296, and F255 play a key role in this activation.
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