The construction of biomaterial supports is vital to the functionality of the supports. The final properties of materials are influenced by the choice of tissue and processing strategy. Traditional tissue reconstruction methods apply a downward flow method to reconstruct the macro- and micro phase features of original tissues, nonetheless these traditional supports ignore the nano scale structures and features that cells are familiar with interrelating at cellâ€“environment interface, and are vital to controlling cell functions, including migration, proliferation, and ECM regeneration (Benoit & Anseth 2005).
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