The key pathological occurrence of serious infection is hemolysis (the bursting of the red blood cells) as a consequence of erythrocyte infestation by sporozoites. This leads to hemolytic anemia and jaundice (Gray et al. 4), which can further lead to anoxia and toxic outcomes thereby causing loss of life and organ breakdown in the absence of medical intervention. The extent of anemia does not correlate with the parasitemia (magnitude of infection or number of parasites in the system) suggesting that other mechanisms play a significant role in the progression of the disease. It is thought that pro-inflammatory cytokines are produced in abundance leading to symptoms such as fever, renal deficiency, clotting difficulties, muscle pain, and low blood pressure.
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