The life cycle of Babesia microti in the human host begins with the transfer of sporozoites from the salivary gland of the tick into the host bloodstream during feeding. Blood transfusion with contaminated blood may also introduce sporozoites into the bloodstream of healthy individuals. The effectiveness of sporozoite transmission is directly proportional to the duration of contact between the tick and the host (Homer et al. 454). The sporozoites infect red blood cells (erythrocytes) where they multiply by binary fission. In the erythrocytes, the sporozoites develop into multinucleated schizonts, which undergo further differentiation to form merozoites. The merozoites grow off from the schizonts. They then lyse the red blood cells and continue infecting other red blood cells. The parasites exhibit a high rate of reproduction that causes immense harm to the host cells.
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